Gene Editing: Medicine’s Most Controversial Technology

Icahn School of Medicine at Mount Sinai

Jacob Appel is Associate Professor of Psychiatry and Medical Education, and Director of Ethics Education in Psychiatry, at the Icahn School of Medicine at Mount Sinai. A bioethicist, physician, lawyer, author and social critic, he is best known for his short stories, his work as a playwright, and his writing in the fields of reproductive ethics, organ donation, neuroethics and euthanasia. Appel’s novel, The Man Who Wouldn’t Stand Up, won the Dundee International Book Prize in 2012. He has taught medical ethics at New York University, Columbia University, and Brown University’s Alpert Medical School.


Advances in genetic editing that have existed for decades only in the fantasies of science fiction writers and the fears of bioethicists have finally arrived in the form of CRISPR: a novel technology for which the Nobel Prize in Chemistry was awarded in 2020.  Scientists now have the power to rapidly and accurately edit the genes of plants, animals and human beings—opening the door to reviving extinct species, curing rare diseases, and even growing organs inside pigs for transplantation into people.  Yet CRISPR also affords the opportunity to edit the human germ lines in radical ways–from creating designer babies to inadvertently culling valuable traits that will be needed in the future. In this talk, bioethicist Jacob Appel reviews the science, history and ethics of the world’s most promising and controversial new technology.



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Richard Williams

Thank you for the informative and interesting lecture.

2 years ago

Very informative

As a biologist, I knew much of what this lecture presented but I did learn a few facts and since it was presented by an ethicist, it explored several aspects that need to be widely discussed. His approach was very “cut and dried” so it was not a dynamic presentation , thus my 4 star rating, but it certainly is worth watching.

1 month ago
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